Development on biosensor for targeted separation and rapid detection for use in complex sample matrices
The project revolves around the preparation of gold coated magnetite nanoparticles with the ability to detect and capture relevant biomedical and environmental analytes. Past project involved the development of ‘dispersible electrodes’ for electrochemical detection of Cu2+ with low detection limits and fast response times.
Selected publications from this work:
- Goon, I.Y., Zhang, C.C., Lim, M., Gooding, J., and Amal, R. (2010), “Controlled fabrication of Polyethylemeimine- functionalized magnetic nanoparticles for the sequestrian and quantification of Free Cu2+”, Langmuir, 26(14), 12247-12252
- Goon, I.Y., Lai, L.M.H., Lim, M., Amal, R., and Gooding, J.J. (2010), “Dispersible electrodes: a solution to slow response times of sensitive sensors”, Chemical Communications, 46(46), 8821-8823
- Lai, L.M.H., Goon, I.Y., Lim, M., Hibbert,D.B., Amal,R. and Gooding (2011), “ Gold coated magnetic nanoparticles as “dispersible electrodes”- Understanding their electrochemical performance”, J. Electroanalytical Chemistry, DOI: 10.1016/j.jelechem.2010.12.016 (article in press, accepted 10/12/2010)
- Lai, L.M.H., Goon, I.Y., Chuah, K., Lim, M., Braet, F., Amal, R., and Gooding, J.J. (2012), “Biochemiresistor: An Ultrasensitive Biosensor for Small Organic Molecules”, Angewandte Chemie, 51(26), 6456-6459
More often than not, harmful bacteria are present at a very low level in a complex food medium that contains myriad of minerals, fats, proteins, and other solids. Such interferences introduce profound challenges into bacteria extraction and identification.
This research will focus on developing extraction system by using magnetic nanoparticles and bacteria virus to capture concentrate harmful bacteria.